CUSTOMER SERVICE * SALES * TECHNICAL SUPPORT

DELIVERIES WORLDWIDE

PERFORMANCE GUARANTEE

Telephone   (804) 318-3686 Toll Free US  (866) 244 1578 Fax         (703) 991-7133 Hours    8 AM - 6 PM EST INTERNATIONAL & DOMESTIC SALES

MANUFACTURING DISTRIBUTION TECHNICAL SERVICES ​FOR ANALYTICAL INSTRUMENTATION

TELEPHONE (804) 318-3686 TOLL FREE  (866) 244-1578

EQUIPMENT FOR QUALITY CONTROL AND R&D  OCCHIO FC200SHR PARTICLE CHARACTERISTIC ANALYZER  SUB VISIBLE PARTICLE AND AGGREGATE DETECTION TO 200 nm OCCHIO FC200S IPAC FOR PROTEIN AGGREGATES APPLICATION

COMPLETE INTERACTIVE SAMPLER CATALOGUE PDF DOWNLOAD ABSOLUTE COUNTING OF PROTEINS SUSPENDED IN A THIN CELL USING HIGH RESOLUTION IMAGING TECHNOLOGY

The Occhio FC200SHR is part of a family of highly sophisticated imaging systems, that are byproducts of a series of collaborative studies in light, imaging, and sample transport, in connection with the University De Liege in Belgium. 

The FC200SHR IPAC, in particular, was developed to solve some of the current technological hurdles with protein aggregate counting. 

HIGH RESOLUTION IMAGING TECHNOLOGY

This high resolution imaging technology, is accomplished in part, by using special backlighting techniques focused from behind the sample. An adjustable range, monochromatic, blue light source has been shown to provide optimal contrast conditions for the particles, and virtually eliminate diffraction. The light is collimated, and acts as a high definition caliper. (Fig. 1.2) In the case of liquids and suspensions, the light flashes simultaneously with a high speed, high definition camera, for extremely robust particle definitions. OCCHIO FLOWCELL TYPE PARTICLE ANALYZER FOR LIQUIDS AND SUSPENSIONS WITH SYRINGE PUMP AND HIGH RESOLUTION CAMERA OPTION FC200S HR

DYNAMIC ANALYSIS IMAGE MAGNIFICATION IS INDEPENDENT OF THE OBJECTS DISTANCE OR POSITION IN THE FIELD OF VIEW

COLLIMATED LIGHT SOURCE ACTS LIKE A CALIPER TO PROVIDE SUPERIOR PARTICLE DEFINITION IN REAL TIME

COMPARISON USING LATEX SPHERES

SUB MICRON DETECTION OF AGGREGATES-In order to improve the quality of the images, the Occhio FC200S HR uses a higher resolution camera, with an optical calibration of .38 microns per pixel, compared with an estimated 1.4 microns per pixel, on a Brightwell DPA 4200. The flow cell on an Occhio FC200S HR, is also half the width at 50 microns. COMPARISON SLIDES OF OPTICAL MICROSCOPY AND NEWLY DEVELOPED DIGITAL IMAGING TECHNIQUES

LIMITATIONS OF EXISTING TECHNOLOGY

• SUB MICRON DETECTION OF AGGREGATES

• LIQUID SUB SAMPLING

• AGGREGATE DIFFERENTIAL SPEEDS

SOLUTIONS TO TECHNOLOGY LIMITATIONS

SUB-MICRONIC DETECTION OF AGGREGATES

• DECREASE THE FLOWCELL THICKNESS TO 50 MICRONS (HALF OF STANDARD FLOW CELL THICKNESS)

• INCREASE OPTICAL CALIBRATION TO 38 MICRONS PER PIXEL

• ENABLE GHOST (TRANSPARENT) PARTICLE DETECTION

• LUT

LIQUID SUB SAMPLING

• USE AN ABSOLUTE SPACER

• HIGH SPEED CAMERA

• PRECISE PUMPING WITH NEW SYRINGE PUIMP

AGGREGATE DIFFERENTIAL SPEED

• AGGREGATE TRACKING ALGORITHM​

SPECIAL SYRINGE PUMP FOR PRECISE SAMPLING . OCCHIO FLOWCELL

WHITESTONE VA TEL (804) 318-3686 FAX (703) 991-7133 INFORMATION@QCLABEQUIPMENT.COM  WWW.QCLABEQUIPMENT.COM Copyright 2012: QAQC Lab | Particle Measurement System | All rights reserved. 804-318-3686 |  sales@qclabequipment.com